A new doctor of medicine investigates the mechanisms of adverse effects caused by excessive physical activity.

Located in the Lt III Postgraduate meeting room, a Doctoral Promotion exam was taking place with promovendus candidate dr. Si Ngurah Oka Putrawan, Sp.PK with the dissertation title "Excessive Physical Training Causing Increased Levels of Tumor Necrosis Factor-α, Increased Malondialdehyde Levels, Decreased Number of Hematopoietic Stem Cells, Decreased Number of CD4+ T Cells in Wistar Rats. Excessive physical training has a negative impact on health and occurs 7-20% in all athletes.Excessive physical training and infection can cause some athletes to fail to perform as expected.Excessive physical training has several negative effects such as induction of inflammation through the production of TNF-α, IL-β, IL-6, IL-10, and CRP, production of reactive oxygen species (ROS) and cause increased production of Malondialdehyde (MDA).Increased proinflammatory cytokines and ROS can inhibit the proliferation and colony formation of haematopoietic stem cells (HSCs)/hematopoietic stem cells, as well as affect the lymphocyte population T-CD4+ cells.This study aims to determine the effect of excessive physical training on p increase in TNF-α and MDA levels, as well as decrease in the number of HSCs and decrease in T-CD4+ cells.

 

From the results of the analysis and discussion it can be concluded that excessive physical training can increase inflammation as reflected in TNF-α levels and oxidative stress which causes an increase in MDA. Excessive physical training also reduced the number of HSCs and CD4+ T cell lymphocytes in wistar rats. This research is a contribution to the development of science which can clarify the pathophysiology of the immunological process in excessive physical exercise which causes an increase in serum TNF-α levels, an increase in serum MDA levels, a decrease in the number of hematopoietic stem cells, a decrease in the number of CD4+ T cells in Wistar rats. It is information, knowledge and reference for practitioners that giving excessive training causes decreased immunity in wistar rats due to a decrease in hematopoietic stem cells and CD4+ T cell lymphocytes.

 

The exam was led by the Dean of the Faculty of Medicine, Udayana University, Dr. dr. Komang Januartha Putra Pinatih, M. Kes with the testing team:

1. Dr. dr. I Made Jawi, M.Kes (Promoter)

2. Prof. Dr. dr. I Wayan Putu Sutirta Yasa, M.Si (Co-promoter I)

3.Dr. dr. A.A Ngurah Subawa, M.Sc (Co-promoter II)

4. Dr. dr. I Made Bakta, Sp. PD-KHOM

5. Prof. Dr. dr. J. Alex Pangkahila, M.Sc.,Sp.And(KSAAM)AIFO-K

6. Dr. Ir. Ida Bagus Putra Manuaba, M. Phil

7. drh. I Nyoman Mantik Astawa, Ph.D

8. Dr. dr. A.A.Wiradewi Lestari, Sp.PK(K)

9.Dr. dr. I Nyoman Wande, S.Ked.,Sp.PK(K)

10.Dr. dr. Susy Purnawati, M.KK

11.Dr. dr. I Wayan Niryana, M.Kes.,Sp.BS(K)

 

While academic invitations are:

1. dr. I Made Winarsa Ruma, S.Ked.,Ph.D

2.Dr. dr. I Made Muliarta, S.Ked., M.Kes

3.Dr. dr. I Putu Eka Widyadharma, M.Sc.,Sp.S(K)

4.Dr. dr. I Wayan Eka Sutyawan, Sp. M(K)

5.Dr. dr. I Gusti Putu Suka Aryana, Sp.PD, K-Ger, FINASIM

 

In this exam, Dr. dr. Si Ngurah Oka Putrawan, Sp.PK was declared to have passed as the 364th Graduate Doctor of the Doctoral Study Program in Medical Sciences, Faculty of Medicine, Udayana University with the title of VERY SATISFACTORY.